Giorgio RUSSO
Adjunct Professor
Giorgio Russo is a Senior Researcher at the National Research Council (CNR) – Institute of Bioimages and Complex Biological Systems (IBSBC), at the Cefalù Secondary Site, which he has been heading since May 2018. He has a background as a specialist in medical physics and as a third-level radiation protection expert. Since March 2025, he has been appointed by the Ministry of Universities and Research (MUR) as the Italian expert for the EURATOM program on fission and fusion within the European Framework Program for Research and Innovation.
He has been an associate researcher at the Southern National Laboratories of the National Institute of Nuclear Physics (LNS – INFN) since 2002; adjunct professor at the University of Palermo since the academic year 2008/09 and at the University of Catania since the academic year 2018/19. He has led international and national research projects, coordinating the CNR unit as activity leader, particularly in the following projects:
- PBCT – Proton Boron Capture Therapy, PRIN 2017 funding type. Funded amount: €1,094,890
- The Breast Integrated Solution (BIS): Technological innovation to support integrated diagnosis and personalized treatment of breast cancer, funded by PR FESR 2021/2027. Funded amount: €525,645.69
- MRgFUS – Development of a technological platform for the non-invasive treatment of oncological and infectious diseases based on the use of focused ultrasound, PON01_01059 project. Funded amount: €1,341,050
- GIOCONDA – Understanding the radiobiological effects of BNCT and Flash therapy, cascade funding under the National Plan for Complementary Investments to the PNRR. Funded amount: €1,091,200
- MIRAGE – MicroRNA-targeted imaging for monitoring and prognostic stratification in neuroendocrine tumors, PNRR Mission 6 – Component 2 Investment 2.1 Enhancement and Strengthening of Biomedical Research in the National Health Service. Funded amount: €1,000,000
All projects share a common approach: multidisciplinary integration and the use of image processing techniques to combine information obtained with biological and/or clinical data.
He is the author of 187 publications in international journals, with 12,018 citations and an H-Index of 32, according to Web of Science.
| A Biological-Driven Approach to Explore Dose-Escalated Ultra-Hypofractionation in Breast Cancer Radiotherapy | BIOMEDICINES |
| From ultrafast laser-generated radiation to clinical impact: a roadmap for radiobiology and cancer research at the extreme light infrastructure (ELI) | EUROPEAN PHYSICAL JOURNAL PLUS |
| Investigating the Influence of Conventional vs. Ultra-High Dose Rate Proton Irradiation Under Normoxic or Hypoxic Conditions on Multiple Developmental Endpoints in Zebrafish Embryos | CANCERS |
| Exploring Dose-Escalated ultra-hypofractionation in Breast Cancer Radiotherapy: an In-Silico, biological-driven study | RADIOTHERAPY AND ONCOLOGY |
| Comparative Evaluation of Machine Learning-Based Radiomics and Deep Learning for Breast Lesion Classification in Mammography | DIAGNOSTICS |
| [18F]PSMA-1007 PET/CT-based radiomics may help enhance the interpretation of bone focal uptakes in hormone-sensitive prostate cancer patients | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Physiopathological effects of entrance versus distal spread-out Bragg peak on mouse spinal cord neurons | SCIENTIFIC REPORTS |
| Ag phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project | APPLIED RADIATION AND ISOTOPES |
| Preclinical Implementation of matRadiomics: A Case Study for Early Malformation Prediction in Zebrafish Model | JOURNAL OF IMAGING |
| Curcumin's Radioprotective Effects on Zebrafish Embryos | ANTIOXIDANTS |
| A Robust [18F]-PSMA-1007 Radiomics Ensemble Model for Prostate Cancer Risk Stratification | JOURNAL OF IMAGING INFORMATICS IN MEDICINE |
| How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? | NPJ MICROGRAVITY |
| Development and Implementation of an Innovative Framework for Automated Radiomics Analysis in Neuroimaging | JOURNAL OF IMAGING |
| A novel boron-conjugated SRC inhibitor for Proton Boron Capture Therapy in glioblastoma treatment | JOURNAL OF INSTRUMENTATION |
| Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice | CANCERS |
| Microglia and glioblastoma heterocellular interplay sustains tumour growth and proliferation as an off-target effect of radiotherapy | CELL PROLIFERATION |
| Biodistribution Assessment of a Novel 68Ga-Labeled Radiopharmaceutical in a Cancer Overexpressing CCK2R Mouse Model: Conventional and Radiomics Methods for Analysis | LIFE-BASEL |
| A Kinetically Controlled Bioconjugation Method for the Synthesis of Radioimmunoconjugates and the Development of a Domain Mapping MS-Workflow for Its Characterization | BIOCONJUGATE CHEMISTRY |
| How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms? | NPJ MICROGRAVITY |
| Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| A Critical Analysis of the Robustness of Radiomics to Variations in Segmentation Methods in 18F-PSMA-1007 PET Images of Patients Affected by Prostate Cancer | DIAGNOSTICS |
| How do gravity alterations affect animal and human systems at a cellular/tissue level? | NPJ MICROGRAVITY |
| Radiomics Analyses to Predict Histopathology in Patients with Metastatic Testicular Germ Cell Tumors before Post-Chemotherapy Retroperitoneal Lymph Node Dissection | JOURNAL OF IMAGING |
| Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model | COMMUNICATIONS BIOLOGY |
| An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics | DIAGNOSTICS |
| Phenotyping the Histopathological Subtypes of Non-Small-Cell Lung Carcinoma: How Beneficial Is Radiomics? | DIAGNOSTICS |
| Spread-Out Bragg Peak in Treatment Planning System by Mixed Integer Linear Programming: a Proof of Concept | 2023 IEEE 36TH INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, CBMS |
| Choline PET/CT features to predict survival outcome in high-risk prostate cancer restaging : a preliminary machine-learning radiomics study | QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| matRadiomics: A Novel and Complete Radiomics Framework, from Image Visualization to Predictive Model | JOURNAL OF IMAGING |
| rtificial intelligence applications on restaging [18F]FDG PET/CT images of metastatic colorectal cancer | JOURNAL OF NUCLEAR MEDICINE |
| 3D DCE-MRI Radiomic Analysis for Malignant Lesion Prediction in Breast Cancer Patients | ACADEMIC RADIOLOGY |
| Radiomics Analysis of Brain [18F]FDG PET/CT to Predict Alzheimer's Disease in Patients with Amyloid PET Positivity: A Preliminary Report on the Application of SPM Cortical Segmentation, Pyradiomics and Machine-Learning Analysis | DIAGNOSTICS |
| A New Preclinical Decision Support System Based on PET Radiomics: A Preliminary Study on the Evaluation of an Innovative 64Cu-Labeled Chelator in Mouse Models | JOURNAL OF IMAGING |
| The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression | BIOMEDICINES |
| Artificial Intelligence Applications on Restaging [18F]FDG PET/CT in Metastatic Colorectal Cancer: A Preliminary Report of Morpho-Functional Radiomics Classification for Prediction of Disease Outcome | APPLIED SCIENCES-BASEL |
| PET Images Atlas-Based Segmentation Performed in Native and in Template Space: A Radiomics Repeatability Study in Mouse Models | IMAGE ANALYSIS AND PROCESSING, ICIAP 2022 WORKSHOPS, PT I |
| On Unsupervised Methods for Medical Image Segmentation: Investigating Classic Approaches in Breast Cancer DCE-MRI | APPLIED SCIENCES-BASEL |
| MRI-Based Radiomics Analysis for Identification of Features Correlated with the Expanded Disability Status Scale of Multiple Sclerosis Patients | IMAGE ANALYSIS AND PROCESSING, ICIAP 2022 WORKSHOPS, PT I |
| matRadiomics: From Biomedical Image Visualization to Predictive Model Implementation | IMAGE ANALYSIS AND PROCESSING, ICIAP 2022 WORKSHOPS, PT I |
| Feasibility on the Use of Radiomics Features of 11[C]-MET PET/CT in Central Nervous System Tumours: Preliminary Results on Potential Grading Discrimination Using a Machine Learning Model | CURRENT ONCOLOGY |
| Biological and Mechanical Characterization of the Random Positioning Machine (RPM) for Microgravity Simulations | LIFE-BASEL |
| Robustness of PET Radiomics Features: Impact of Co-Registration with MRI | APPLIED SCIENCES-BASEL |
| Radiobiological Outcomes, Microdosimetric Evaluations and Monte Carlo Predictions in Eye Proton Therapy | APPLIED SCIENCES-BASEL |
| Semi-automated and interactive segmentation of contrast-enhancing masses on breast DCE-MRI using spatial fuzzy clustering | BIOMEDICAL SIGNAL PROCESSING AND CONTROL |
| The Proton-Boron Reaction Increases the Radiobiological Effectiveness of Clinical Low- and High-Energy Proton Beams: Novel Experimental Evidence and Perspectives | FRONTIERS IN ONCOLOGY |
| Artificial intelligence applications in medical imaging: A review of the medical physics research in Italy | PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS |
| Radiomics features of 11[C]-MET PET/CT in primary brain tumors: preliminary results on grading discrimination using a machine learning model | JOURNAL OF NUCLEAR MEDICINE |
| Hypoxia Transcriptomic Modifications Induced by Proton Irradiation in U87 Glioblastoma Multiforme Cell Line | JOURNAL OF PERSONALIZED MEDICINE |
| A Computational Study on Temperature Variations in MRgFUS Treatments Using PRF Thermometry Techniques and Optical Probes | JOURNAL OF IMAGING |
| Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram | APPLIED SCIENCES-BASEL |
| A quantum-inspired classifier for clonogenic assay evaluations | SCIENTIFIC REPORTS |
| Radiomics analysis of 18F-Choline PET/CT in the prediction of disease outcome in high-risk prostate cancer: an explorative study on machine learning feature classification in 94 patients | EUROPEAN RADIOLOGY |
| Transcriptional modulations induced by proton irradiation in mice skin in function of adsorbed dose and distance | JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES |
| Using Deep Learning for Fast Dose Refinement in Proton Therapy | 2021 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC) |
| Local Disease-Free Survival Rate (LSR) Application to Personalize Radiation Therapy Treatments in Breast Cancer Models | JOURNAL OF PERSONALIZED MEDICINE |
| Lung Segmentation on High-Resolution Computerized Tomography Images Using Deep Learning: A Preliminary Step for Radiomics Studies | JOURNAL OF IMAGING |
| The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance | CANCERS |
| A preliminary PET radiomics study of brain metastases using a fully automatic segmentation method | BMC BIOINFORMATICS |
| 18F-Choline PET/CT in the evaluation of high-risk prostate cancer outcome: an explorative study on radiomics feature classification for prediction of disease progression | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Molecular Investigation on a Triple Negative Breast Cancer Xenograft Model Exposed to Proton Beams | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| Non-invasive ablation of cardiac arrhythmia. Is proton radiation therapy a step forward? | INTERNATIONAL JOURNAL OF CARDIOLOGY |
| SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP | PLOS ONE |
| New Artificial intelligence model for 18F-Choline PET/CT in evaluation of high-risk prostate cancer outcome: texture analysis and radiomics features classification for prediction of disease progression | JOURNAL OF NUCLEAR MEDICINE |
| Development of a new fully three-dimensional methodology for tumours delineation in functional images | COMPUTERS IN BIOLOGY AND MEDICINE |
| MF2C3: Multi-Feature Fuzzy Clustering to Enhance Cell Colony Detection in Automated Clonogenic Assay Evaluation | SYMMETRY-BASEL |
| Performance of Radiomics Features in the Quantification of Idiopathic Pulmonary Fibrosis from HRCT | DIAGNOSTICS |
| Assessment of Lung Cancer Development in Idiopathic Pulmonary Fibrosis Patients Using Quantitative High-Resolution Computed Tomography A Retrospective Analysis | JOURNAL OF THORACIC IMAGING |
| Radiomics: A New Biomedical Workflow to Create a Predictive Model | MEDICAL IMAGE UNDERSTANDING AND ANALYSIS |
| Tissue Classification to Support Local Active Delineation of Brain Tumors | MEDICAL IMAGE UNDERSTANDING AND ANALYSIS, MIUA 2019 |
| A Survey on Nature-Inspired Medical Image Analysis: A Step Further in Biomedical Data Integration | FUNDAMENTA INFORMATICAE |
| Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| A semi-automatic approach for epicardial adipose tissue segmentation and quantification on cardiac CT scans | COMPUTERS IN BIOLOGY AND MEDICINE |
| Choline-PET Radiomic features to predict survival outcome in prostate cancer | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| SPM MRI-less 18F-Florbetaben PET for amyloid burden quantification and potential AD patients selection in clinical trials | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| A Machine Learning Segmentation Approach For The Extraction Of Radiomic Features In PET Studies | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Potential clinical value of quantitative fluorine-18-fluorodeoxyglucose-PET/computed tomography using a graph-based method analysis in evaluation of incidental lesions of gastrointestinal tract: correlation with endoscopic and histopathological findings | NUCLEAR MEDICINE COMMUNICATIONS |
| Potential clinical value of quantitative fluorine-18-fluorodeoxyglucose-PET/computed tomography using a graph-based method analysis in evaluation of incidental lesions of gastrointestinal tract: correlation with endoscopic and histopathological findings. | Nuclear medicine communications |
| Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| Radiosensitizing effect of curcumin-loaded lipid nanoparticles in breast cancer cells | SCIENTIFIC REPORTS |
| Gene Expression Profiles Induced by High-dose Ionizing Radiation in MDA-MB-231 Triple-negative Breast Cancer Cell Line | CANCER GENOMICS & PROTEOMICS |
| Proton-irradiated breast cells: molecular points of view | JOURNAL OF RADIATION RESEARCH |
| A novel framework for MR image segmentation and quantification by using MedGA | COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE |
| Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources | SCIENTIFIC REPORTS |
| 18F-Florbetaben PET/CT to Assess Alzheimer's Disease: A new Analysis Method for Regional Amyloid Quantification | JOURNAL OF NEUROIMAGING |
| K-nearest neighbor driving active contours to delineate biological tumor volumes | ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE |
| Active contour algorithm with discriminant analysis for delineating tumors in positron emission tomography | ARTIFICIAL INTELLIGENCE IN MEDICINE |
| Treatment of juxta-anastomotic stenoses for failing distal radiocephalic arteriovenous fistulas: Drug-coated balloons versus angioplasty | JOURNAL OF VASCULAR ACCESS |
| Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations | PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS |
| Computer-Assisted Approaches for Uterine Fibroid Segmentation in MRgFUS Treatments: Quantitative Evaluation and Clinical Feasibility Analysis | QUANTIFYING AND PROCESSING BIOMEDICAL AND BEHAVIORAL SIGNALS |
| Quantum-inspired minimum distance classification in a biomedical context | INTERNATIONAL JOURNAL OF QUANTUM INFORMATION |
| Assessment of survival in patients with idiopathic pulmonary fibrosis using quantitative HRCT indexes | MULTIDISCIPLINARY RESPIRATORY MEDICINE |
| A smart and operator independent system to delineate tumours in Positron Emission Tomography scans | COMPUTERS IN BIOLOGY AND MEDICINE |
| Preliminary study of novel SRC tyrosine kinase inhibitor and proton therapy combined effect on glioblastoma multiforme cell line: In vitro evaluation of target therapy for the enhancement of protons effectiveness | NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS |
| Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility | PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS |
| Assessment of survival in patients with idiopathic pulmonary fibrosis (IPF) using quantitative HRCT indexes | EUROPEAN RESPIRATORY JOURNAL |
| GTVcut for neuro-radiosurgery treatment planning: an MRI brain cancer seeded image segmentation method based on a cellular automata model | NATURAL COMPUTING |
| [18F]FDG and [18F]FLT PET for the evaluation of response to neo-adjuvant chemotherapy in a model of triple negative breast cancer | PLOS ONE |
| Radiation Gene-expression Signatures in Primary Breast Cancer Cells | ANTICANCER RESEARCH |
| Radiation-Induced Gene Expression Changes in High and Low Grade Breast Cancer Cell Types | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| NeXt for neuro-radiosurgery: A fully automatic approach for necrosis extraction in brain tumor MRI using an unsupervised machine learning technique | INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY |
| First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness | SCIENTIFIC REPORTS |
| Combinatorial optimisation in radiotherapy treatment planning | AIMS MEDICAL SCIENCE |
| Gene expression profiling of breast cancer cell lines treated with proton and electron radiations | BRITISH JOURNAL OF RADIOLOGY |
| Analysis of Metabolic Parameters Coming from Basal and Interim PET in Hodgkin Lymphoma | CURRENT MEDICAL IMAGING REVIEWS |
| Summary of tumor size of treated animals at baseline (pre) and at the end of PTX treatment (post) and the corresponding Tumor Volume Response (TVR) categorization. | Figshare |
| Fully Automatic Multispectral MR Image Segmentation of Prostate Gland Based on the Fuzzy C-Means Clustering Algorithm | MULTIDISCIPLINARY APPROACHES TO NEURAL COMPUTING |
| Radiobiological models towards a personalized radiation oncology | TRANSLATIONAL CANCER RESEARCH |
| Radiogenomics: the utility in patient selection | TRANSLATIONAL CANCER RESEARCH |
| A fully automatic approach for multimodal PET and MR image segmentation in gamma knife treatment planning | COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE |
| Automated Prostate Gland Segmentation Based on an Unsupervised Fuzzy C-Means Clustering Technique Using Multispectral T1w and T2w MR Imaging | INFORMATION |
| An enhanced random walk algorithm for delineation of head and neck cancers in PET studies | MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING |
| Multiparametric MRI Apparent Diffusion Coefficient (ADC) Accuracy in Diagnosing Clinically Significant Prostate Cancer | IN VIVO |
| Prompt gamma-ray emission for future imaging applications in proton-boron fusion therapy | JOURNAL OF INSTRUMENTATION |
| Study of gamma-ray emission by proton beam interaction with injected Boron atoms for future medical imaging applications | JOURNAL OF INSTRUMENTATION |
| Preliminary study for small animal preclinical hadrontherapy facility | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT |
| Recurrent bladder carcinoma: clinical and prognostic role of 18 F-FDG PET/CT | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| HIGH-INTENSITY FOCUSED ULTRASOUND-AND RADIATION THERAPY-INDUCED IMMUNO-MODULATION: COMPARISON AND POTENTIAL OPPORTUNITIES | ULTRASOUND IN MEDICINE AND BIOLOGY |
| Predictive and Prognostic Value of Early Disease Progression by PET Evaluation in Advanced Non-Small Cell Lung Cancer | ONCOLOGY |
| Cytokine profile of breast cell lines after different radiation doses | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY |
| Delayed luminescence in a multiparameter approach to evaluation and reduction of radiobiological risks | NOVEL BIOPHOTONICS TECHNIQUES AND APPLICATIONS IV |
| Confirmatory biopsy of men under active surveillance: extended versus saturation versus multiparametric magnetic resonance imaging/transrectal ultrasound fusion prostate biopsy | SCANDINAVIAN JOURNAL OF UROLOGY |
| Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma | JOURNAL OF THERAPEUTIC ULTRASOUND |
| Recent developments in GEANT4 | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT |
| Recurrent bladder carcinoma: clinical and prognostic role of 18F-FDG PET/TC | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Radiobiological Effectiveness of Ultrashort Laser-Driven Electron Bunches: Micronucleus Frequency, Telomere Shortening and Cell Viability | RADIATION RESEARCH |
| Evaluation of erlotinib treatment response in non-small cell lung cancer using metabolic and anatomic criteria | QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Correlation between histological grade and positron emission tomography parameters in cervical carcinoma | ONCOLOGY LETTERS |
| LESM: a laser-driven sub-MeV electron source delivering ultra-high dose rate on thin biological samples | JOURNAL OF PHYSICS D-APPLIED PHYSICS |
| Combining split-and-merge and multi-seed region growing algorithms for uterine fibroid segmentation in MRgFUS treatments | MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING |
| A fully automatic method for biological target volume segmentation of brain metastases | INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY |
| Detection rate for significant cancer at confirmatory biopsy in men enrolled in Active Surveillance protocol: 20 cores vs 30 cores vs MRI/TRUS fusion prostate biopsy | ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA |
| Semi-automatic Brain Lesion Segmentation in Gamma Knife Treatments Using an Unsupervised Fuzzy C-Means Clustering Technique | ADVANCES IN NEURAL NETWORKS: COMPUTATIONAL INTELLIGENCE FOR ICT |
| Neuro-Radiosurgery Treatments: MRI Brain Tumor Seeded Image Segmentation Based on a Cellular Automata Model | CELLULAR AUTOMATA, ACRI 2016 |
| Predictive and prognostic value of early pet evaluation on disease progression of advanced non-small cell lung cancer | ANNALS OF ONCOLOGY |
| Evaluation of Platinum-based Therapy Response in Non-Small Cell Lung Cancer | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| CIRCULATING ARGINASE-1 IN SERUM IS A NOVEL BIO-MARKERIN HODGKIN LYMPHOMA | HAEMATOLOGICA |
| An Automatic Method for PET Delineation of Cervical Tumors | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Dosimetry for electron Intra-Operative Radio Therapy: Comparison of output factors obtained through alanine/EPR pellets, ionization chamber and Monte Carlo-GEANT4 simulations for IORT mobile dedicate accelerator | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS |
| Gamma Knife treatment planning: MR brain tumor segmentation and volume measurement based on unsupervised Fuzzy C-Means clustering | INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY |
| A fully automatic 2D segmentation method for uterine fibroid in MRgFUS treatment evaluation | COMPUTERS IN BIOLOGY AND MEDICINE |
| Monte Carlo application based on GEANT4 toolkit to simulate a laser-plasma electron beam line for radiobiological studies | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT |
| Gene Expression Profiling of MCF10A Breast Epithelial Cells Exposed to IOERT | ANTICANCER RESEARCH |
| High-dose Ionizing Radiation Regulates Gene Expression Changes in the MCF7 Breast Cancer Cell Line | ANTICANCER RESEARCH |
| A GEANT4 web-based application to support Intra-Operative Electron Radiotherapy using the European grid infrastructure | CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE |
| Study of the role of particle-particle dipole interaction in dielectrophoretic devices for biomarkers identification | SENSORS |
| Metabolic Response Assessment in Non-Small Cell Lung Cancer Patients after Platinum-Based Therapy: A Preliminary Analysis | CURRENT MEDICAL IMAGING REVIEWS |
| An Automatic Method for Metabolic Evaluation of Gamma Knife Treatments | IMAGE ANALYSIS AND PROCESSING - ICIAP 2015, PT I |
| Arginase-1 Is Increased in Hodgkin Lymphoma, Associated to Poor Outcome and Positively Correlated to Semiquantitative PET ParameterS | BLOOD |
| Experimental evidence for the use of ultrasound to increase tumor-cell radiosensitivity | TRANSLATIONAL CANCER RESEARCH |
| High intensity focused ultrasounds Preface | TRANSLATIONAL CANCER RESEARCH |
| A daily quality assurance routine for ultrasounds in vitro experiments | TRANSLATIONAL CANCER RESEARCH |
| Cancer Therapy Combining High-Intensity Focused Ultrasound and Megavoltage Radiation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS |
| Theoretical and experimental study of the role of cell-cell dipole interaction in dielectrophoretic devices: application to polynomial electrodes | BIOMEDICAL ENGINEERING ONLINE |
| EVALUATION OF ERLOTINIB TREATMENT RESPONSE IN NON-SMALL CELL LUNG CANCER USING EORTC METABOLIC CRITERIA, PERCIST AND ANATOMIC CRITERIA RECIST | JOURNAL OF THORACIC ONCOLOGY |
| Metabolic and anatomic criteria use in evaluation of Erlotinib treatment response | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Genotyping analysis and 18FDG uptake in breast cancer patients: a preliminary research | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH |
| High-intensity focused ultrasound plus concomitant radiotherapy: a new weapon in oncology? | Journal of therapeutic ultrasound |
| High-intensity focused ultrasound plus concomitant radiotherapy: a new weapon in oncology? | JOURNAL OF THERAPEUTIC ULTRASOUND |
| Small-scale laser based electron accelerators for biology and medicine: a comparative study of the biological effectiveness | LASER ACCELERATION OF ELECTRONS, PROTONS, AND IONS II; AND MEDICAL APPLICATIONS OF LASER-GENERATED BEAMS OF PARTICLES II; AND HARNESSING RELATIVISTIC PLASMA WAVES III |
| A Semi-Automatic Multi-Seed Region-Growing Approach for Uterine Fibroids Segmentation in MRgFUS Treatment | 2013 SEVENTH INTERNATIONAL CONFERENCE ON COMPLEX, INTELLIGENT, AND SOFTWARE INTENSIVE SYSTEMS (CISIS) |
| Gene expression profiles in irradiated cancer cells | 2ND ELIMED WORKSHOP AND PANEL |
| Monte Carlo Simulation for the Transport Beamline | 2ND ELIMED WORKSHOP AND PANEL |
| A Graph-Based Method for PET Image Segmentation in Radiotherapy Planning: A Pilot Study | IMAGE ANALYSIS AND PROCESSING (ICIAP 2013), PT II |
| SUV-volume Histogram as tool for MRgFUS bone metastasis treatment monitoring | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Correlation between 18FDG PET SUV with Partial Volume Correction and MRS Choline signal integral in breast cancer | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Metabolic monitoring of MRgFUS treatment in bone metastasis using 18F-FDG PET/CT: A case report | JOURNAL OF NUCLEAR MEDICINE |
| Metabolic Changes After MRgFUS Treatment Of A Bone Metastasis Using PET/CT: a Case Report | 12TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND |
| Dose distribution changes with shielding disc misalignments and wrong orientations in breast IOERT: a Monte Carlo-GEANT4 and experimental study | JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS |
| Can magnetic resonance image-guided focused ultrasound surgery replace local oncology treatments? A review | TUMORI JOURNAL |
| Clinical assessment of a recovery coefficients-based partial volume correction in 18F-FDG PET-CT oncological studies | JOURNAL OF NUCLEAR MEDICINE |
| A PET Prototype for In-Beam Monitoring of Proton Therapy | IEEE TRANSACTIONS ON NUCLEAR SCIENCE |
| Dosimetric and clinical experience in eye proton treatment at INFN-LNS | PERSPECTIVES IN NUCLEAR PHYSICS |
| Hadrontherapy: an Open Source, Geant4-based application for proton-ion therapy studies | 2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5 |
| Preliminary results of an in-beam PET prototype for proton therapy | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT |
| Experimental validation of the filtering approach for dose monitoring in proton therapy at low energy | PHYSICA MEDICA |
| Monte Carlo validation of EYEPLAN proton therapy treatment planning | NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS |
| Proton therapy detector studies under the experience gained at the CATANA facility | NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS |
| Online monitor detector for the protontherapy beam at the INFN Laboratori Nazionali del Sud-Catania | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT |
| Geant4-based Monte Carlo simulation of the Leksell Gamma Knife® | 2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11 |
| A PET prototype for in-beam monitoring of proton therapy | 2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11 |
| Geant4 developments and applications | IEEE TRANSACTIONS ON NUCLEAR SCIENCE |
| Validation of Geant4 Physics Models for the Simulation of the Proton Bragg Peak | 2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6 |
| The GEANT4 toolkit capability in the hadron therapy field: simulation of a transport beam line | NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS |
| Implementation of a new Monte Carlo - GEANT4 simulation tool for the development of a proton therapy beam line and verification of the related dose distributions | IEEE TRANSACTIONS ON NUCLEAR SCIENCE |
| Detailed Monte Carlo investigation of a proton computed tomography system | 2005 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5 |
| Monte Carlo simulation of a clinical beam line: Geant4 and GRID technology approach | 2004 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-7 |
| Implementation of a new Monte Carlo simulation tool for the development of a proton therapy beam line and verification of the related dose distributions | 2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5 |
| Monte Carlo based implementation of an energy modulation system for proton therapy | 2004 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-7 |
Medical Physics and Radiation Protection
Specialist in medical physics and certified third-level radiation protection expert.
Research activities focus on clinical applications and safety protocols in radiological technologies.
Technologies for Integrated Diagnosis and Therapy
Leader of the BIS project, aimed at developing technological solutions for integrated diagnosis and personalized treatment of breast cancer.
Work emphasizes the integration of advanced imaging techniques with clinical and biological data to enhance diagnostic accuracy and therapeutic planning.
Radiobiology and Advanced Therapies
Principal investigator in the GIOCONDA project, investigating the radiobiological effects of Boron Neutron Capture Therapy (BNCT) and Flash Therapy.
Research includes cellular mechanism analysis and optimization of therapeutic protocols to improve efficacy and safety.
Molecular Imaging and Biomarkers
Coordinator of the MIRAGE project, focused on microRNA-targeted imaging for monitoring and prognostic stratification in neuroendocrine tumors.
Adopts a multidisciplinary approach combining molecular imaging technologies with biological and clinical data integration.
Activities as Radiation Protection Expert
Provides radiation protection expertise for public and private facilities in the healthcare, industrial, and research sectors, including:
- Nuclear Medicine Department and PET Cyclotron Center at AOE Cannizzaro
- University of Catania
- INFN – Southern National Laboratories (LNS) and INFN Catania Section